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Simple amino acid substitutions or sequence modifications of the endogenous GLP-1 to avoid proteolysis lead to a modest increase in GLP-1 RA half-life from 2 min to 2-3 hours, resulting in the twice- and once-daily products Byetta and Adlyxin, respectively

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Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]

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